[WCIR2009]P.Reaven教授访谈:关于肠促胰岛素的一些观点
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专家访谈 临床科研 综合领域 作者未知 来源:未知 2009/11/25 9:12:00    加入收藏
内容概要:《国际糖尿病》:目前对肠促胰岛素的关注越来越多,并且对其研究的也越来越深入,然而,其在血管功能方面的有益作用却较少为人所知,您能简单探讨一下其对血管的影响吗?

  《国际糖尿病》:目前对肠促胰岛素的关注越来越多,并且对其研究的也越来越深入,然而,其在血管功能方面的有益作用却较少为人所知,您能简单探讨一下其对血管的影响吗?

    International Diabetes:There has been intensive discussions and increasing popularity of incretins.  However its beneficial effects on cardiovascular function is lesser known.  Could you briefly discuss the vascular effects of incretin?

    Peter Reaven教授:好的。正如你所说,关于肠促胰岛素,目前我们所掌握的信息大多是其对血糖的直接控制作用,已经有颇为有力的数据显示其对心血管危险因素包括血压、空腹脂质水平以及餐后葡萄糖减少的存在着长期作用。这种长期的影响很有可能改善心血管危险因素,或者实际上具有改善心血管危险因素的这种潜能,或者确实具有减少心血管疾病发生危险的作用。但是越来越明显的是GLP-1自身或者可能是其代谢产物例如GLP-1 (9-36)片段,它们对心血管也具有直接的影响。

    Dr Peter Reaven:  Well as you say most of the information we currently have is really directed towards the effect of incretins on glycemic control and there has been fairly impressive data on the chronic use of incretins on cardiovascular risk factors including blood pressure fasting lipid levels and in addition to the post prandial reduction in glucose.  It is very likely the long term effects of these improve standard cardiovascular risk factors will in fact have potential, or do have potential to reduce cardiovascular risk but what is now becoming apparent is that GLP 1 itself and perhaps metabolites such as GLP 1 (9-36) fragment they also have direct cardiovascular effects as well.
 



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